How to Train Your Dragon breathed new life into the weekend box office with a $43.3 million debut to easily grab the No. 1 spot, according to studio estimates released Sunday.

The DreamWorks Animation adventure knocked off Tim Burton and Johnny Depp's Alice in Wonderland, which finished second at $17.3 million. Alice had won the box office the past three weekends since being released.

John Cusack's raunchy comedy Hot Tub Time Machine debuted in third place at $13.7 million, just ahead of the Gerard Butler and Jennifer Aniston film The Bounty Hunter, which held strong in its second week at $12.4 million.

Diary of a Wimpy Kid slipped to fifth place at $10 million to round out the weekend top five.


Weekend Box Office

1. How to Train Your Dragon, $43.3 million.

2. Alice in Wonderland, $17.3 million.

3. Hot Tub Time Machine, $13.7 million.

4. The Bounty Hunter, $12.4 million.

5. Diary of a Wimpy Kid, $10 million.

6. She's Out of My League, $3.5 million.

7. Green Zone, $3.3 million.

8. Shutter Island, $3.2 million.

9. Repo Men, $3 million.

10. Our Family Wedding, $2.2 million.