Melissa Satta spent her childhood between Sardinia and United States. At 16 she began modeling in Sardinia, winning some local beauty contests.

At 17 she won Miss Muretto and moved to Milan for work as a professional model.

In 2004 she started work on Italian TV in the program Mio fratello รจ pakistano then she became the brunette velina of Striscia la notizia (from 2005).

Beginning at the age of 19 she has a contract with the Riccardo Gay agency, one of the most important model agencies in Italy. She also has a relationship with one of Italy's prominent football strikers, Christian Vieri.